Oligoria: disinterest in former friends or hobbies.Lethonomia: a tendency to forget, or inability to recall, names.Cenotaph: a monument erected as a memorial to a dead person or dead people buried elsewhere, especially those killed fighting a war.Here are just a few of the interesting words you'll learn: All of them apply to the aged, a group that makes up an increasing portion of the population-particularly in the United States, Europe, and Japan. Most of these words are unusual, rare, obsolete, archaic, wonderful, marvelous, arcane, and even preposterous.
COMPENDIUM SYNONYM FULL
D - query term matched full text in FDA drug labels.There are many words relating to old age, aging, and the elderly, and this compendium of words seeks to help you understand almost two thousand of them. C - query term matched short drug description text. B - query term matched disease term in drug contraindications or off-label uses, targets listed in drug bioactivity profiles (not MoA targets), or pharmacologic action descriptions. Ranked result list is annotated with 4 level ranking system ordered from highest to lowest: A - query term matched drug name or synonyms, mechanism of action target, or drug indication. Example search for “HMG-CoA Reductase Inhibitor” FDA EPC term for statin drugs returns list of all statin drugs classified by FDA as HMG-CoA reductase inhibitors.
Dogs, cattle, and cats sum up to 63% of the indications covered by 193 veterinary drugs. DrugCentral currently holds 1664 indications (pairs of drug and concept names) for 34 species. DrugCentral veterinary data contains application numbers and types, trade names, applicant names, and prescription types for 1492 drug products as referenced in FDA’s Green Book.
COMPENDIUM SYNONYM UPDATE
The current update adds 1805 bioactivities for 226 veterinary drugs and 804 targets. New! Veterinary Drugs, Uses & Products: Drug Central now contains Veterinary Drugs, Uses & Products.Returned drugs are ranked using the following criteria: top ranked drugs have mechanism of action target Mu-type opioid receptor, next in the list are drugs with potencies measured against this receptor. Terms: “OPRM1”, P35372, “OPRM_HUMAN”, full or partial
Target search example: Supported target search terms are HUGO gene symbols, Uniprot accessions and target names, and Swissprot identifiers.Įxample search for drugs targeting Mu-type opioid receptor can be run using either of the The target cards depict the "Accession", "Swissprot", "Organism", "Gene" & "Target class" followed by "Drug relations" where the drugs "Bioactivity mechanism-of-actions" are identified. To perform a target card search enter a Uniprot target Accession ID e.g., P23975. The 2022 version goes further by computing adverse drug event scores granulated by age: pediatric data (FAERS_PED) covers patients from 1 day to 17 years, and geriatric data (FAERS_GER) focuses on elderly patients over 65 years of age, respectively.įemale, Male, Geriatric & Pediatrics. The 2021 DrugCentral update, we separately calculated FAERS for men and women to enable research on sex differences in drug safety. SMILES strings can be located on all Drug Cards under "Description". Typing a SMILES string in the DrugCentral Substructure search bar launches a chemical substructure search that finds matching compounds in DrugCentral. The current update supports chemical substructure searching. New! Medical (off label) uses suggestion form Off label Uses Form Indicated to treat “Chronic Hepatitis C” followed by drugs For drugs approved after 2012 disease annotations are extracted manually from approved drug labels and mapped to SNOMED-CT concepts. Disease annotations for drugs approved before 2012 originate from OMOP vocabulary mappings. Generic drug names, drug synonyms, trade names terms can be used to search for drugs.Įxample search for Lipitor can query using either “Atorvastatin” or “Lipitor”.A comprehensive list of drug development codes and salt or ester formsĪre also stored in the database and can be used as search terms, for example search for "rosuvastatin" the following terms can be used: "rosuvastatin calcium" or "ZD4522".ĭisease search example: Supported disease terms are SNOMED-CT and OMOP vocabulary terms. Makena Venetoclax Dapagliflozin KEYTRUDA Sacubitril LORBRENA Hydroxychloroquine The Latest in Chemistry in Coronavirus Research Featured News Drugcentral 2023 NAR Article
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